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ALT and increased levels of rats weight. But there was no significant change in serum Bil. and ALP , and there was no significant change in levels of urine creatinine and total antioxidant capacity of urine and plasma. Conclusion: Those results suggest that aqueous extract of Rosa damascena has protective and therapeutic , at the special doses , on liver damage induced by CCl4&induced liver damage , by oral administration of Rosa damascena extract , specially at the dose of 25 mg/kg , as evident from decreased levels of serum AST - ALT). but there was no significant change in ALP and serum bilirubin. The results showed that significant hepatoprotective effect was obtained against CCl4&250 g) were selected for the study and maintained at standard conditions. Animals , after weighing , were divided into five groups with six animals in each group as follows: Positive control: treated with water for 7 days , followed by CCl4 on day 7.Negative control: treated with water for 7 days. Groups , , : treated with extract of Rosa damascena at doses of 100 , 50 and 25 mg/kg daily for 7 days , followed by CCl4 on day 7 , respectively. Urines of rats were collected by metabolic cage on 7th day. On the 10th day after secondary weighing. The animals were sacrificed under ether anesthesia and then blood were collected. Serum was used for biochemical estimations. Results: Administration of CCl4 to rats caused significant increase in serum transaminases (AST -albino rats (200-mediated hepatotoxicity was chosen as the experimental model. Design and methods: 30 male Wistar-induced liver damage are similar to that of acute viral hepatitis, in this study CCl4-induced hepatic injury. CCl4 is a potent hepatotoxin and since the changes associated with CCl4-Background and aim: Several therapeutic effects have been described for the flowers of "Rosa damascene". And members of the Rosaceae family have been used for food and medicinal purpose. In the present investigation , the hepatoprotective and antioxidant activity of Rosa damascena extract was evaluated against CCl4
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